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Weight loss plateaus are normal physiological responses caused by metabolic adaptation, changes in body composition, and reduced energy expenditure

Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase

The results showed comparable reduction in HbA1c levels, along with similar outcomes across key parameters including fasting plasma glucose (FPG), postprandial glucose (PPG) & weight loss

Chem Biol Drug Design (2015) 86:148290

Reduced Nutrient Intake Lower calorie intake may lead to reduced consumption of essential nutrients if diet quality is not maintained